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Germ cell lineage differentiation in non‐seminomatous germ cell tumours

4 Nov 2005

Abstract excerpt

Human germ cell tumours (GCTs) have long fascinated investigators for a number of reasons. Being pluripotential tumours, they can differentiate into both extra-embryonic and embryonic (somatic) tissues. However, it has never been shown convincingly that, in humans, these tumours are truly totipotent and can also give rise to the germ lineage, the third major differentiation lineage occurring early during...

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PMID: 16273510
DOI: 10.1002/path.1872

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