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Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population.

Thrombosis and haemostasis - 1 Sept 2005

Guéant-Rodriguez Rosa-Maria, Juilliére Yves, Candito Mirande, Adjalla Charles E, Gibelin Pierre, Herbeth Bernard, Van Obberghen Emmanuel, Gueánt Jean-Louis

Abstract excerpt

Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) is an established determinant of homocysteine plasma level (t-Hcys) while its association with coronary artery disease (CAD) seems to be more limited. In contrast, the association of the substitutions A2756G of methionine synthase (MTR), A66G of methionine synthase reductase (MTRR) and C776G of transcobalamin (TCN) to both t-Hcys and CAD needs to be...

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Source

Identifiers

PMID: 16268464
DOI: 10.1160/TH05-04-0262

Genes

CAD
MTHFR
MTRR
MTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population.PMID 16268464Read ↗

High plasma homocysteine is associated with the risk of coronary artery disease independent of methylenetetrahydrofolate reductase 677C-->T genotypes.Semantic proximity Read ↗

Influence of methionine synthase (A2756G) and methionine synthase reductase (A66G) polymorphisms on plasma homocysteine levels and relation to risk of coronary artery disease.Semantic proximity Read ↗

C677T mutation of methylenetetrahydrofolate reductase gene and serum homocysteine levels in Turkish patients with coronary artery disease.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene polymorphism and its association with coronary artery disease.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid.Semantic proximity Read ↗

Correlation between C677T MTHFR gene polymorphism, plasma homocysteine levels and the incidence of CAD.Semantic proximity Read ↗

Folate gene polymorphisms MTR A2756G, MTRR A66G, and BHMT G742A and risk for coronary artery disease: a meta-analysis.Semantic proximity Read ↗

Homocysteine and the MTHFR 677C-->T allele in premature coronary artery disease. Case control and family studies.Semantic proximity Read ↗

The 677 C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels.Semantic proximity Read ↗

The role of methylenetetrahydrofolate reductase C677T gene polymorphism as a risk factor for coronary artery disease: a cross-sectional study in the Sidoarjo Regional General Hospital.Semantic proximity Read ↗

[Evaluation of MTHFR C677T gene polymorphism and homocysteine level in coronary atherosclerotic disease].Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate, and vitamin B12 levels and the extent of coronary artery diseaseSemantic proximity Read ↗

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