Article
Haptoglobin phenotype 2-2 as a potentially new risk factor for spontaneous venous thromboembolism.
Haematologica - 1 Nov 2005
Vormittag Rainer, Vukovich Thomas, Mannhalter Christine, Minar Erich, Schönauer Verena, Bialonczyk Christine, Hirschl Mirko, Pabinger Ingrid
Abstract excerpt
BACKGROUND AND OBJECTIVES: Haptoglobin (Hp) is a plasma protein that binds free hemoglobin and thus prevents catalysis of reactive oxygen species by the Fenton reaction. A genetic polymorphism has been described that leads to the generation of two distinct alleles, Hp1 and Hp2, which define three major haptoglobin phenotypes, denoted Hp1-1, Hp2-1 and Hp2-2. Hp2-2 has been reported to be associated with the risk...
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