Article
Growth factor-sensitive molecular targets identified in primary and metastatic head and neck squamous cell carcinoma using microarray analysis.
Oral oncology - 1 Mar 2006
Miyazaki Hiroshi, Patel Vyomesh, Wang Huixin, Ensley John F, Gutkind J Silvio, Yeudall W Andrew
Abstract excerpt
Polypeptide growth factors play key roles in the processes of cell migration and invasion. In this study, we have used cDNA microarrays to identify target genes whose expression is differentially modulated by the growth factors TGFbeta and EGF. HN4 and HN12 cell lines, established from primary tumor and a lymph node metastasis arising in one patient with head and neck squamous cell carcinoma, were treated with...
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