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Expression profiling of genes regulated by TGF-beta: Differential regulation in normal and tumour cells

11 Apr 2007

Abstract excerpt

BACKGROUND: TGF-beta is one of the key cytokines implicated in various disease processes including cancer. TGF-beta inhibits growth and promotes apoptosis in normal epithelial cells and in contrast, acts as a pro-tumour cytokine by promoting tumour angiogenesis, immune-escape and metastasis. It is not clear if various actions of TGF-beta on normal and tumour cells are due to differential gene regulations. Hence...

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PMID: 17425807
DOI: 10.1186/1471-2164-8-98

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