Article
A quantitative approach to catabolite repression in Escherichia coli.
The Journal of biological chemistry - 3 Feb 2006
Bettenbrock Katja, Fischer Sophia, Kremling Andreas, Jahreis Knut, Sauter Thomas, Gilles Ernst-Dieter
Abstract excerpt
A dynamic mathematical model was developed to describe the uptake of various carbohydrates (glucose, lactose, glycerol, sucrose, and galactose) in Escherichia coli. For validation a number of isogenic strains with defined mutations were used. By considering metabolic reactions as well as signal transduction processes influencing the relevant pathways, we were able to describe quantitatively the phenomenon of...
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