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Article

Computer-aided rational design of the phosphotransferase system for enhanced glucose uptake in Escherichia coli.

Molecular systems biology - 1 Jan 2008

Nishio Yousuke, Usuda Yoshihiro, Matsui Kazuhiko, Kurata Hiroyuki

Abstract excerpt

The phosphotransferase system (PTS) is the sugar transportation machinery that is widely distributed in prokaryotes and is critical for enhanced production of useful metabolites. To increase the glucose uptake rate, we propose a rational strategy for designing the molecular architecture of the Escherichia coli glucose PTS by using a computer-aided design (CAD) system and verified the simulated results with...

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Identifiers

PMID: 18197177
DOI: 10.1038/msb4100201
PMCID: PMC2238713

Genes

PTS
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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