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Article

Common beta-lactamases inhibit bacterial biofilm formation.

Molecular microbiology - 1 Nov 2005

Gallant Claude V, Daniels Craig, Leung Jacqueline M, Ghosh Anindya S, Young Kevin D, Kotra Lakshmi P, Burrows Lori L

Abstract excerpt

Beta-lactamases, which evolved from bacterial penicillin-binding proteins (PBPs) involved in peptidoglycan (PG) synthesis, confer resistance to beta-lactam antibiotics. While investigating the genetic basis of biofilm development by Pseudomonas aeruginosa, we noted that plasmid vectors encoding the common beta-lactamase marker TEM-1 caused defects in twitching motility (mediated by type IV pili), adherence and...

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Identifiers

PMID: 16262787
DOI: 10.1111/j.1365-2958.2005.04892.x
PMCID: PMC3097517

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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