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Article

Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin.

mBio - 25 Aug 2015

Scherr Tyler D, Hanke Mark L, Huang Ouwen, James David B A, Horswill Alexander R, Bayles Kenneth W, Fey Paul D, Torres Victor J, Kielian Tammy

Abstract excerpt

UNLABELLED: The macrophage response to planktonic Staphylococcus aureus involves the induction of proinflammatory microbicidal activity. However, S. aureus biofilms can interfere with these responses in part by polarizing macrophages toward an anti-inflammatory profibrotic phenotype. Here we demonstrate that conditioned medium from mature S. aureus biofilms inhibited macrophage phagocytosis and induced...

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Source

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Identifiers

PMID: 26307164
DOI: 10.1128/mBio.01021-15
PMCID: PMC4550693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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