Article
Neuron-to-astrocyte transition: phenotypic fluidity and the formation of hybrid asterons in differentiating neurospheres.
The Journal of comparative neurology - 19 Dec 2005
Laywell Eric D, Kearns Sean M, Zheng Tong, Chen K Amy, Deng Jie, Chen Huan-Xin, Roper Steven N, Steindler Dennis A
Abstract excerpt
To the extent that their fate choice and differentiation processes can be understood and manipulated, neural stem cells represent a promising therapeutic tool for a variety of neuropathologies. We have previously shown that mature astrocytes possess neural stem cell attributes, and can give rise to neurons through the formation of multipotent neurosphere clones. Here we show that relatively mature neurons...
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