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Two cases of non-small cell lung cancer patients with somatic or germline EGFR R776H mutation.

Lung cancer (Amsterdam, Netherlands) - 1 Nov 2021

Guo Tianxing, Zhu Lihuan, Li Wujin, Lin Rongjia, Ding Yun, Kang Qiaolin, Shao Lin, Li Chanhe, Pan Xiaojie

Abstract excerpt

The development of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) has revolutionized the treatment for non-small cell lung cancer (NSCLC). Comprehensive genomic profiling for NSCLC enables clinicians to identify more uncommon genetic alterations in EGFR. It remains unclear whether patients with certain rare EGFR mutations can benefit from EGFR inhibitors. On the other hand, emerging...

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PMID: 34555730
DOI: 10.1016/j.lungcan.2021.05.036

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