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Article

Regulation of the Cyclin-Dependent Kinase Inhibitor p57Kip2 Expression by p63

22 Aug 2005

Abstract excerpt

The cyclin-dependent kinase (CDK) inhibitor p57Kip2 is a negative regulator of cell proliferation, binding to a variety of cyclin-CDK complexes and inhibiting their kinase activities. The p57Kip2 gene was recognized as a target gene for p73beta, one member of the p53 family. In spite of this, the phenotypes of p73 and p57Kip2 knockout mice do not resemble each other while there is a phenotypic overlap between the...

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PMID: 16258268
DOI: 10.4161/cc.4.11.2135

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