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Article

Investigating the effect of ribavirin treatment on genetic mutations in Crimean-Congo haemorrhagic fever virus (CCHFV) through next-generation sequencing.

Journal of medical virology - 1 Feb 2023

D'Addiego Jake, Elaldi Nazif, Wand Nadina, Osman Karen, Bagci Binnur Koksal, Kennedy Emma, Pektas Ayse Nur, Hart Eilish, Slack Gillian, Hewson Roger

Abstract excerpt

Crimean-Congo haemorrhagic fever (CCHF) is the most widespread tick-borne viral haemorrhagic fever affecting humans, and yet a licensed drug against the virus (CCHFV) is still not available. While several studies have suggested the efficacy of ribavirin against CCHFV, current literature remains inconclusive. In this study, we have utilised next-generation sequencing to investigate the mutagenic effect of...

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PMID: 36734067
DOI: 10.1002/jmv.28548

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