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Article

Sortase A contributes to pneumococcal nasopharyngeal colonization in the chinchilla model.

FEMS microbiology letters - 1 Dec 2005

Chen Shu, Paterson Gavin K, Tong Hua Hua, Mitchell Timothy J, DeMaria Thomas F

Abstract excerpt

Sortase A (SrtA) is required to anchor neuraminidase, beta-galactosidase, and possibly other LPXTG motif proteins to the pneumococcal cell surface. We examined the role of SrtA in Streptococcus pneumoniae nasopharyngeal (NP) colonization in the chinchilla model. The srtA mutant colonized the nasopharynx at a significantly lower level than the D39 parent strain during the second and third week of the carriage, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16246506
DOI: 10.1016/j.femsle.2005.09.052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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