Article
Disruption of srtA gene in Streptococcus suis results in decreased interactions with endothelial cells and extracellular matrix proteins.
Veterinary microbiology - 18 Mar 2008
Vanier G, Sekizaki T, Domínguez-Punaro M C, Esgleas M, Osaki M, Takamatsu D, Segura M, Gottschalk M
Abstract excerpt
Streptococcus suis, a major pathogen of swine, is an emerging zoonotic agent which causes meningitis and septic shock. In this study, we investigated the ability of S. suis mutant strain (SRTDeltaA) lacking the sortase A gene (srtA) to interact with host cells and extracellular matrix (ECM) proteins, as well as its virulence in a mouse infection model. We demonstrated that mutant SRTDeltaA had reduced capacity to...
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