Hepatocyte growth factor accelerates the proliferation of hepatic oval cells and possibly promotes the differentiation in a 2‐acetylaminofluorene/partial hepatectomy model in rats

Abstract excerpt

BACKGROUND: Hepatocyte growth factor (HGF) is the primary agent promoting the proliferation of mature hepatocytes. The purpose of the present paper was to clarify the effects of HGF on the proliferation and differentiation of hepatic oval cells using a 2-acetylaminofluorene/partial hepatectomy (2-AAF/PH) model in rats. METHODS: Recombinant human HGF (0.2 mg/day) was administered to 2-AAF/PH rats for 7 days using...

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