Article
Impaired transcriptional upregulation of Parkin promoter variant under oxidative stress and proteasomal inhibition: clinical association.
Human genetics - 1 Dec 2005
Tan E K, Puong K Y, Chan D K Y, Yew K, Fook-Chong S, Shen H, Ng P W, Woo J, Yuen Y, Pavanni R, Wong M C, Puvan K, Zhao Y
Abstract excerpt
We provided data to show that the transcriptional activity of wildtype -258T in the parkin promoter region was significantly higher than the -258G variant in human cell lines. The transcriptional activity of wildtype -258T was significantly increased under oxidative stress by hydrogen peroxide, but this was not observed for the -258G variant. The transcriptional upregulation was significantly higher for wildtype...
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