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Article

Genetic analysis of absB, a Streptomyces coelicolor locus involved in global antibiotic regulation.

Journal of bacteriology - 1 Jul 1992

Adamidis T, Champness W

Abstract excerpt

The filamentous soil bacterium Streptomyces coelicolor is known to produce four antibiotics which are genetically and structurally distinct. An extensive search for antibiotic regulatory mutants led to the discovery of absB mutants, which are antibiotic deficient but sporulation proficient. Genetic analysis of the absB mutants has resulted in definition of the absB locus at 5 o'clock on the genetic map. Multiple...

Topics

Anthraquinones
Anti-Bacterial Agents
Crosses, Genetic
Gene Expression Regulation, Bacterial
Genes, Regulator
Multigene Family
Mutagenesis
Mutation
Streptomyces

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1624449
DOI: 10.1128/jb.174.14.4622-4628.1992
PMCID: PMC206257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1624449-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genetic analysis of absB, a Streptomyces coelicolor locus involved in global antibiotic regulation.PMID 1624449Read ↗

Global negative regulation of Streptomyces coelicolor antibiotic synthesis mediated by an absA-encoded putative signal transduction system.Semantic proximity Read ↗

Mutations in a new Streptomyces coelicolor locus which globally block antibiotic biosynthesis but not sporulation.Semantic proximity Read ↗

Novel two-component systems implied in antibiotic production in Streptomyces coelicolor.Semantic proximity Read ↗

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Antibiotic Production and Antibiotic Resistance: The Two Sides of AbrB1/B2, a Two-Component System of Streptomyces coelicolorSemantic proximity Read ↗

Regulation of the Streptomyces coelicolor calcium-dependent antibiotic by absA, encoding a cluster-linked two-component system.Semantic proximity Read ↗

Transcriptional regulation of Streptomyces coelicolor pathway-specific antibiotic regulators by the absA and absB loci.Semantic proximity Read ↗

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Transcriptional activation of the pathway-specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor.Semantic proximity Read ↗

SCO6992, a Protein with β-Glucuronidase Activity, Complements a Mutation at the absR Locus and Promotes Antibiotic Biosynthesis in Streptomyces coelicolor.Semantic proximity Read ↗

Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1.Semantic proximity Read ↗

Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2).Semantic proximity Read ↗

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