Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional analysis of doxorubicin-induced cardiotoxicity

26 Oct 2005

Abstract excerpt

Doxorubicin is an effective chemotherapeutic agent against a broad range of tumors. However, a threshold dose of doxorubicin causes an unacceptably high incidence of heart failure and limits its clinical utility. We have established two models of doxorubicin cardiotoxicity in mice: 1) in an acute model, mice are treated with 15 mg/kg of doxorubicin once; and 2) in a chronic model, they receive 3 mg/kg weekly for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemotherapy-induced cardiotoxicity and mitigation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 16243910
DOI: 10.1152/ajpheart.00832.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional analysis of doxorubicin-induced cardiotoxicityPMID 16243910Read ↗

Progressive suppression of DNA repair genes with persistent p53 activation in Doxorubicin-treated cardiomyocytesSemantic proximity Read ↗

Integrated Omics Approach to Delineate the Mechanisms of Doxorubicin-Induced CardiotoxicitySemantic proximity Read ↗

Early effects of doxorubicin in perfused heart: transcriptional profiling reveals inhibition of cellular stress response genesSemantic proximity Read ↗

Sex Differences in Doxorubicin‐Induced Cardiotoxicity: Insights from Transcriptome AnalysisSemantic proximity Read ↗

Differential Impact of Doxorubicin Dose on Cell Death and Autophagy Pathways during Acute CardiotoxicitySemantic proximity Read ↗

Transcriptomic profiling reveals p53 as a key regulator of doxorubicin-induced cardiotoxicitySemantic proximity Read ↗

Transcriptomic Insights into Early Diagnosis of Doxorubicin-Induced Cardiotoxicity in a Rat ModelSemantic proximity Read ↗

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessmentSemantic proximity Read ↗

The anti-cancer drug doxorubicin induces substantial epigenetic changes in cultured cardiomyocytesSemantic proximity Read ↗

Persistent Alterations to the Gene Expression Profile of the Heart Subsequent to Chronic Doxorubicin TreatmentSemantic proximity Read ↗

Transcriptome Profiling of Peripheral Blood Cells Identifies Potential Biomarkers for Doxorubicin Cardiotoxicity in a Rat ModelSemantic proximity Read ↗

Redd1 knockdown prevents doxorubicin-induced cardiac senescence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.