Article
Paraoxonase 1 gene Q192R polymorphism affects stroke and myocardial infarction risk.
Clinical biochemistry - 1 Mar 2006
Baum Larry, Ng Ho Keung, Woo Kam Sang, Tomlinson Brian, Rainer Timothy Hudson, Chen Xiangyan, Cheung Wing Sze, Chan Daniel Kam Yin, Thomas G Neil, Tong Cindy See Wai, Wong Ka Sing
Abstract excerpt
OBJECTIVES: Paraoxonase (PON1), an enzyme associated with high-density lipoprotein (HDL) particles, inhibits oxidation and atherogenesis. We sought to investigate the association of the PON1 Q192R polymorphism with stroke and heart disease. DESIGN AND METHODS: In a case control study, we genotyped 242 ischemic stroke, 231 myocardial infarction (MI), and 310 healthy control subjects, all Chinese. RESULTS:...
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