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Article

High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease.

The Journal of biological chemistry - 30 Dec 2005

Pears Michael R, Cooper Jonathan D, Mitchison Hannah M, Mortishire-Smith Russell J, Pearce David A, Griffin Julian L

Abstract excerpt

The neuronal ceroid lipofuscinoses (NCLs) constitute a range of progressive neurological disorders primarily affecting children. Although six of the causative genes have been characterized, the underlying disease pathogenesis for this family of disorders is unknown. Using a metabolomics approach...

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Identifiers

PMID: 16239221
DOI: 10.1074/jbc.M507380200

Genes

NCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16239221-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease.PMID 16239221Read ↗

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