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Article

Altered flurothyl seizure induction latency, phenotype, and subsequent mortality in a mouse model of juvenile neuronal ceroid lipofuscinosis/batten disease.

Epilepsia - 1 Oct 2002

Kriscenski-Perry Elizabeth, Applegate Craig D, Serour Andrew, Mhyre Timothy R, Leonardo Christopher C, Pearce David A

Abstract excerpt

PURPOSE: Juvenile neuronal ceroid lipofuscinosis (JNCL), or Batten disease, is a pediatric neurodegenerative disease characterized by vision loss, seizure activity, cognitive decline, and premature death. Discovery of the Batten disease-related gene, CLN3, led to creation of a Cln3 protein-deficient mouse model (Cln3-/-), which recapitulates some of the histopathologic characteristics of the human condition. We...

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Source

Identifiers

PMID: 12366726
DOI: 10.1046/j.1528-1157.2002.16002.x

Genes

CLN3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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