Article

CLN3 deficiency leads to neurological and metabolic perturbations during early development

2023-03-17

Abstract excerpt

Juvenile Neuronal Ceroid Lipofuscinosis (or Batten disease) is an autosomal recessive, rare neurodegenerative disorder that affects mainly children above the age of 5 years and is most commonly caused by mutations in the highly conserved CLN3 gene. Here, we generated cln3 morphants and stable mutant lines in zebrafish. Although neither morphant nor mutant cln3 larvae showed any obvious developmental or morpholo...

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Literature Corpus work: fd529c60-5a41-56f8-8c79-cc8eafbe712b
DOI: 10.1101/2023.03.17.533107

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