Article
Mamu-I: a novel primate MHC class I B-related locus with unusually low variability.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2000
Urvater J A, Otting N, Loehrke J H, Rudersdorf R, Slukvin I I, Piekarczyk M S, Golos T G, Hughes A L, Bontrop R E, Watkins D I
Abstract excerpt
The rhesus macaque is an important animal model for several human diseases and organ transplantation. Therefore, definition of the MHC of this species is crucial to the development of these models. Unfortunately, unlike humans, lymphocytes from a single rhesus macaque express up to 12 different MHC class I cDNAs. From which locus these various alleles are derived is unclear. In our attempts to define the MHC...
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