Article
Interaction of genetic predisposition and environmental factors in the pathogenesis of idiopathic orthostatic intolerance.
The American journal of the medical sciences - 1 Nov 1999
Jordan J, Shannon J R, Jacob G, Pohar B, Robertson D
Abstract excerpt
BACKGROUND: The hemodynamic and autonomic abnormalities in idiopathic orthostatic intolerance (IOI) have been studied extensively. However, the mechanisms underlying these abnormalities are not understood. If genetic predisposition were important in the pathogenesis of IOI, monozygotic twins of patients with IOI should have similar hemodynamic and autonomic abnormalities. METHODS: We studied two patients with IOI...
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