Article
Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases.
Cellular and molecular life sciences : CMLS - 1 Dec 2005
Matsushima N, Tachi N, Kuroki Y, Enkhbayar P, Osaki M, Kamiya M, Kretsinger R H
Abstract excerpt
A number of human diseases have been shown to be associated with mutation in the genes encoding leucine-rich-repeat (LRR)-containing proteins. They include 16 different LRR proteins. Mutations of these proteins are associated with 19 human diseases. The mutations occur frequently within the LRR domains as well as their neighboring domains, including cysteine clusters. Here, based on the sequence analysis of the...
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