Article

LIM domain-wide comprehensive mutagenesis reveals the role of leucine in CSRP3 protein stability

2021-06-28

Abstract excerpt

Cardiomyopathies are a severe and chronic cardiovascular burden worldwide, affecting a large cohort in the general population. Cysteine and glycine-rich protein 3 (CSRP3) is one of key proteins implicated in dominant dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM). In this study, we device a rapid in-silico screening protocol that creates a mutational landscape map for all possible allowed and d...

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Literature Corpus work: bc88ba25-bacd-5736-bd17-397ee0ca913f
DOI: 10.1101/2021.06.27.450078

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