Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypermethylation, Loss of Expression of Glutathione Peroxidase-3 in Barrett's Tumorigenesis

1 Sept 2005

Abstract excerpt

Chronic gastroesophageal reflux disease is a known risk factor for Barrett's esophagus (BE), which induces oxidative mucosal damage. Glutathione peroxidase-3 (GPx3) is a secretory protein with potent extracellular antioxidant activity. In this study, we have investigated the mRNA and protein expression of GPx3, and explored promoter hypermethylation as an epigenetic mechanism for GPx3 gene inactivation during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bladder and Urothelial Cancer Treatments
Share to Esophageal and GI Pathology
Share to Esophageal Cancer Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16229808
DOI: 10.1593/neo.05328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypermethylation, Loss of Expression of Glutathione Peroxidase-3 in Barrett's TumorigenesisPMID 16229808Read ↗

DNA hypermethylation regulates the expression of members of the Mu-class glutathione <i>S</i>-transferases and glutathione peroxidases in Barrett’s adenocarcinomaSemantic proximity Read ↗

Loss of glutathione peroxidase 3 expression is correlated with epigenetic mechanisms in endometrial adenocarcinomaSemantic proximity Read ↗

Insights into the role of GPX3, a highly efficient plasma antioxidant, in cancer.Semantic proximity Read ↗

Glutathione Peroxidase 3, Deleted or Methylated in Prostate Cancer, Suppresses Prostate Cancer Growth and MetastasisSemantic proximity Read ↗

Promoter hypermethylation and inactivation of O6-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell linesSemantic proximity Read ↗

Reduced Expression of GPX3 in Breast Cancer Patients in Correlation with Clinical SignificanceSemantic proximity Read ↗

Promoter Hypermethylation of the RUNX3 Gene in Esophageal Squamous Cell CarcinomaSemantic proximity Read ↗

Loss of Runx3 is a key event in inducing precancerous state of the stomach.Semantic proximity Read ↗

Functional glutathione peroxidase 3 polymorphisms associated with increased risk of Taiwanese patients with gastric cancer.Semantic proximity Read ↗

Metallothionien 3 expression is frequently down-regulated in oesophageal squamous cell carcinoma by DNA methylationSemantic proximity Read ↗

Tissue inhibitor of metalloproteinase‐3 (<i>TIMP‐3</i>) gene is methylated in the development of esophageal adenocarcinoma: Loss of expression correlates with poor prognosisSemantic proximity Read ↗

<i>CDX2</i> promoter methylation is not associated with mRNA expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.