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Metallothionien 3 expression is frequently down-regulated in oesophageal squamous cell carcinoma by DNA methylation

1 Dec 2005

Abstract excerpt

BACKGROUND: Metallothionein 3 (MT3) inhibits growth in a variety of cell types. We measured MT3 gene expression by RT-PCR, and DNA methylation in the MT3 promoter by combined bisulphite restriction analysis, in four oesophageal cancer cell lines and the resected oesophagus from 64 patients with oesophageal squamous cell carcinoma (SCC). RESULTS: MT3 expression was not detected in one of the four oesophageal cell...

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PMID: 16351731
DOI: 10.1186/1476-4598-4-42

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