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Article

Examination of VLC-PUFA-deficient photoreceptor terminals.

Investigative ophthalmology & visual science - 24 Apr 2014

Bennett Lea D, Hopiavuori Blake R, Brush Richard S, Chan Michael, Van Hook Matthew J, Thoreson Wallace B, Anderson Robert E

Abstract excerpt

PURPOSE: Juvenile-onset autosomal dominant Stargardt-like macular dystrophy (STGD3) is caused by mutations in ELOVL4 (elongation of very long fatty acids-4), an elongase necessary for the biosynthesis of very long chain fatty acids (VLC-FAs ≥ C26). Photoreceptors are enriched with VLC polyunsaturated fatty acids (VLC-PUFAs), which are necessary for long-term survival of rod photoreceptors. The purpose of these...

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Share to Electroretinography
Share to Fatty Acids, Unsaturated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macular Degeneration

Share to Microscopy, Electron, Transmission

Share to Photoreceptor Cells, Vertebrate

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Source

Open in PubMed Open full text

Identifiers

PMID: 24764063
DOI: 10.1167/iovs.14-13997
PMCID: PMC4083770

Genes

ELOVL4
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

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Examination of VLC-PUFA-deficient photoreceptor terminals.PMID 24764063Read ↗

Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration.Semantic proximity Read ↗

The Elovl4 Spinocerebellar Ataxia-34 Mutation 736T>G (p.W246G) Impairs Retinal Function in the Absence of Photoreceptor Degeneration.Semantic proximity Read ↗

Elovl4 5-bp deletion does not accelerate cone photoreceptor degeneration in an all-cone mouse.Semantic proximity Read ↗

Current Progress in Deciphering Importance of VLC-PUFA in the Retina.Semantic proximity Read ↗

In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4.Semantic proximity Read ↗

Mutant ELOVL4 that causes autosomal dominant stargardt-3 macular dystrophy is misrouted to rod outer segment disks.Semantic proximity Read ↗

Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration.Semantic proximity Read ↗

Haploinsufficiency is not the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease.Semantic proximity Read ↗

Mouse Models of Stargardt 3 Dominant Macular Degeneration.Semantic proximity Read ↗

Retinal pathology and skin barrier defect in mice carrying a Stargardt disease-3 mutation in elongase of very long chain fatty acids-4.Semantic proximity Read ↗

Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death.Semantic proximity Read ↗

Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acidsSemantic proximity Read ↗

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