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Article

The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.

Molecular and cellular biology - 1 Aug 2003

Scheper Gert C, Parra Josep L, Wilson Mary, Van Kollenburg Barbara, Vertegaal Alfred C O, Han Ze-Guang, Proud Christopher G

Abstract excerpt

The cap-binding eukaryotic initiation factor eIF4E is phosphorylated by the mitogen-activated protein (MAP) kinase-interacting kinases (Mnk's). Three forms of the Mnk's exist in human cells: Mnk1, Mnk2a, and Mnk2b. These last two are derived from the same gene by alternative splicing and differ o...

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Source

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Identifiers

PMID: 12897141
DOI: 10.1128/MCB.23.16.5692-5705.2003
PMCID: PMC166352

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12897141-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.PMID 12897141Read ↗

The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).Semantic proximity Read ↗

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eEF2K as an important kinase associated with cancer survival and prognosisSemantic proximity Read ↗

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Isoform-Specific Localization Diversifies Human MSI2 FunctionSemantic proximity Read ↗

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development.Semantic proximity Read ↗

A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha.Semantic proximity Read ↗

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