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Article

In Vivo Genetic Selection of Renal Proximal Tubules

11 Oct 2005

Abstract excerpt

Repopulation by transplanted cells can result in effective therapy for several regenerative organs including blood, liver, and skin. In contrast, cell therapies for renal diseases are not currently available. Here we developed an animal model in which cells genetically resistant to a toxic intermediate of tyrosine metabolism, homogentisic acid (HGA), were able to repopulate the damaged proximal tubule epithelium...

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PMID: 16216560
DOI: 10.1016/j.ymthe.2005.09.004

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