Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1

27 Jul 2016

Abstract excerpt

We tested the hypothesis that ex vivo hepatocyte gene therapy can correct the metabolic disorder in fumarylacetoacetate hydrolase-deficient (Fah(-/-)) pigs, a large animal model of hereditary tyrosinemia type 1 (HT1). Recipient Fah(-/-) pigs underwent partial liver resection and hepatocyte isolation by collagenase digestion. Hepatocytes were transduced with one or both of the lentiviral vectors expressing the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Metabolism and Genetic Disorders
Share to Virus-based gene therapy research
Share to Xenotransplantation and immune response

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27464750
DOI: 10.1126/scitranslmed.aaf3838

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1PMID 27464750Read ↗

Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease.Semantic proximity Read ↗

In vivo lentiviral vector gene therapy to cure hereditary tyrosinemia type 1 and prevent development of precancerous and cancerous lesionsSemantic proximity Read ↗

Ectopic hepatocyte transplantation cures the pig model of tyrosinemiaSemantic proximity Read ↗

<i>In vivo</i> lentiviral vector gene therapy to cure hereditary tyrosinemia type 1 and prevent development of precancerous and cancerous lesionsSemantic proximity Read ↗

Curative Ex Vivo Hepatocyte-Directed Gene Editing in a Mouse Model of Hereditary Tyrosinemia Type 1Semantic proximity Read ↗

Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1.Semantic proximity Read ↗

EX VIVO GENE EDITING AND CELL THERAPY FOR HEREDITARY TYROSINEMIA TYPE 1Semantic proximity Read ↗

<i>Ex Vivo</i> Hepatic Gene Therapy of a Mouse Model of Hereditary Tyrosinemia Type ISemantic proximity Read ↗

Efficient production of Fah -null heterozygote pigs by chimeric adeno-associated virus-mediated gene knockout and somatic cell nuclear transferSemantic proximity Read ↗

Ex Vivo Hepatocyte Reprograming Promotes Homology‐Directed DNA Repair to Correct Metabolic Disease in Mice After TransplantationSemantic proximity Read ↗

Messenger RNA as a Source of Transposase for Sleeping Beauty Transposon–mediated Correction of Hereditary Tyrosinemia Type ISemantic proximity Read ↗

Gene therapy in liver diseases: state-of-the-art and future perspectives.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.