Article
[Genetic variation-- important for the clinical effect of opioids?].
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke - 6 Oct 2005
Klepstad Pål, Dale Ola, Borchgrevink Petter C, Kaasa Stein, Skorpen Frank
Abstract excerpt
The individual variability of opioid pharmacology suggests that the patients' genetic disposition influences the response to opioids. Given the complexity of morphine pharmacology, variability may be caused by several genes. Data suggest that variability in genes encoding the enzyme metabolising morphine (UGT2B7 gene), mu-opioid receptors (OPRM1 gene) and BBB transport of morphine by multidrug resistance...
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