Article
Genotypically defined lissencephalies show distinct pathologies.
Journal of neuropathology and experimental neurology - 1 Oct 2005
Forman Mark S, Squier Waney, Dobyns William B, Golden Jeffrey A
Abstract excerpt
Lissencephaly is traditionally divided into 2 distinct pathologic forms: classic (type I) and cobblestone (type II). To date, mutations in 4 genes, LIS1, DCX, RELN, and ARX, have been associated with distinct type I lissencephaly syndromes. Each of these genes has been shown to play a role in normal cell migration, consistent with the presumed pathogenesis of type I lissencephaly. Based on these data, we...
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