The clinical patterns and molecular genetics of lissencephaly and subcortical band heterotopia

Abstract excerpt

Lissencephaly (LIS) or “smooth brain” and the related malformation known as subcortical band heterotopia (SBH)—also called “double cortex”—are the classic malformations associated with deficient neuronal migration and abnormal formation of cerebral convolutions or gyri. Although known from pathologic studies for more than a century (Matell, 1893; Culp, 1914; Erhardt, 1914), these malformations were brought to...

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