Article
A bi-functional siRNA construct induces RNA interference and also primes PCR amplification for its own quantification.
Nucleic acids research - 7 Oct 2005
Jiang Ming, Arzumanov Andrey A, Gait Michael J, Milner Jo
Abstract excerpt
RNA interference (RNAi) is a process of post-transcriptional gene silencing initiated by double-stranded RNAs, including short interfering RNA (siRNA). Silencing is sequence-specific and RNAi has rapidly become central to the study of gene function. RNAi also carries promise for selective silencing of viral and endogenous genes causal for disease. To detect the very low levels of siRNA effective for RNAi we...
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