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Article

Vγ9Vδ2 T Cell Response to Colon Carcinoma Cells

1 Oct 2005

Abstract excerpt

During analysis of CD8 T cells derived from ascites of a colon cancer patient, we isolated a Vgamma9Vdelta2 T cell clone showing strong reactivity against autologous tumor cell lines. This clone killed a large fraction of allogeneic colon carcinoma and melanoma cell lines, but did not affect a normal colon cell line, colon fibroblasts, or melanocytes. Tumor cell recognition was TCR and NKG2D dependent and induced...

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PMID: 16210656
DOI: 10.4049/jimmunol.175.8.5481

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