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Article

WT1 is a tumor‐associated antigen in colon cancer that can be recognized by <i>in vitro</i> stimulated cytotoxic T cells

9 Jan 2004

Abstract excerpt

The Wilms' tumor suppressor gene (WT1) has been shown to be overexpressed in acute and chronic leukemias and in a variety of solid human malignancies, including cancers of the breast and lung. In our present study, we investigated the potential role of WT1 gene in human colon cancer. WT1 mRNA and protein expression was analyzed in a panel of human colon cancer cell lines and primary colon carcinomas by RT-PCR and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 14961577
DOI: 10.1002/ijc.11721

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WT1 is a tumor‐associated antigen in colon cancer that can be recognized by <i>in vitro</i> stimulated cytotoxic T cellsPMID 14961577Read ↗

Mapping of novel peptides of WT-1 and presenting HLA alleles that induce epitope-specific HLA-restricted T cells with cytotoxic activity against WT-1(+) leukemias.Semantic proximity Read ↗

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Peptide-Specific CARs Recognize WT1 Promiscuously Presented by Diverse HLA Class II AllelesSemantic proximity Read ↗

Spontaneous high clonal expansion of Wilms’ tumor gene 1 (WT1)-specific cytotoxic T-lymphocytes in patients with WT1-expressing solid tumorSemantic proximity Read ↗

Allogeneic HLA-A*02–Restricted WT1-Specific T Cells from Mismatched Donors Are Highly Reactive but Show Off-Target PromiscuitySemantic proximity Read ↗

Structures of native and affinity-enhanced WT1 epitopes bound to HLA-A*0201: implications for WT1-based cancer therapeutics.Semantic proximity Read ↗

Mutation or loss of Wilms' tumor gene 1 (WT1) are not major reasons for immune escape in patients with AML receiving WT1 peptide vaccination.Semantic proximity Read ↗

Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO miceSemantic proximity Read ↗

Safety and persistence of WT1-specific T-cell receptor gene−transduced lymphocytes in patients with AML and MDSSemantic proximity Read ↗

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Frameshift-mutation-derived peptides as tumor-specific antigens in inherited and spontaneous colorectal cancer.Semantic proximity Read ↗

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