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γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

11 Jan 2023

Abstract excerpt

Abstract DNA mismatch repair-deficient (MMR-d) cancers present an abundance of neoantigens that is thought to explain their exceptional responsiveness to immune checkpoint blockade (ICB) 1,2 . Here, in contrast to other cancer types 3–5 , we observed that 20 out of 21 (95%) MMR-d cancers with genomic inactivation of β2-microglobulin (encoded by B2M ) retained responsiveness to ICB, suggesting the involvement of...

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PMID: 36631610
DOI: 10.1038/s41586-022-05593-1

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