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Article

Phosphorylation of serine 212 confers novel activity to human estrogen receptor α.

Steroids - 1 Apr 2012

Shindo Sawako, Sakuma Tsutomu, Negishi Masahiko, Squires James

Abstract excerpt

Estrogen receptor α (ERα) can be phosphorylated at various residues, one of which is serine 212 in the DNA binding domain. The majority of human nuclear receptors conserves, as a motif, this serine residue within their DNA binding domain. Among these nuclear receptors, phosphorylation of the corresponding threonine 38 in the nuclear receptor CAR is essential for determining its activity [9]. Here, we have...

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Source

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Identifiers

PMID: 22266331
DOI: 10.1016/j.steroids.2012.01.001
PMCID: PMC4033595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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