Article
Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference.
Human genetics - 1 Dec 2005
Huang Shurong, Chen Lishan, Libina Nataliya, Janes Joel, Martin George M, Campisi Judith, Oshima Junko
Abstract excerpt
The great majority of cases of the Hutchinson-Gilford progeroid syndrome (HGPS) ("Progeria of Childhood'') are caused by a single nucleotide mutation (1824 C->T) in the LMNA gene which encodes lamin A and C, nuclear intermediate filaments that are important components of the nuclear lamina. The resultant mutant protein (Delta50 lamin A) is thought to act in a dominant fashion. We exploited RNA interference...
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