Article
Rsc4 connects the chromatin remodeler RSC to RNA polymerases.
Molecular and cellular biology - 1 Jul 2006
Soutourina Julie, Bordas-Le Floch Véronique, Gendrel Gabrielle, Flores Amando, Ducrot Cécile, Dumay-Odelot Hélène, Soularue Pascal, Navarro Francisco, Cairns Bradley R, Lefebvre Olivier, Werner Michel
Abstract excerpt
RSC is an essential, multisubunit chromatin remodeling complex. We show here that the Rsc4 subunit of RSC interacted via its C terminus with Rpb5, a conserved subunit shared by all three nuclear RNA polymerases (Pol). Furthermore, the RSC complex coimmunoprecipitated with all three RNA polymerases. Mutations in the C terminus of Rsc4 conferred a thermosensitive phenotype and the loss of interaction with Rpb5....
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