Article
Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek's disease virus.
Proceedings of the National Academy of Sciences of the United States of America - 7 Feb 2006
Brown Andrew C, Baigent Susan J, Smith Lorraine P, Chattoo Jason P, Petherbridge Lawrence J, Hawes Pippa, Allday Martin J, Nair Venugopal
Abstract excerpt
Marek's disease virus (MDV) is an oncogenic herpesvirus that induces fatal T cell lymphomas in chickens. With more than 20 billion doses of vaccine used annually, vaccination constitutes the cornerstone of Marek's disease control. Despite the success of vaccination, evolution of virulence among MDV strains continues to threaten the effectiveness of the current Marek's disease vaccines. MDV-encoded protein MEQ...
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