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Homodimerization of Marek's Disease Virus-Encoded Meq Protein Is Not Sufficient for Transformation of Lymphocytes in Chickens

30 Oct 2008

Abstract excerpt

Marek's disease virus (MDV), the etiologic agent of Marek's disease, is a potent oncogenic herpesvirus. MDV is highly contagious and elicits a rapid onset of malignant T-cell lymphomas in chickens within several weeks after infection. MDV genome codes an oncoprotein, Meq, which shares resemblance with the Jun/Fos family of bZIP transcription factors. Similar to Jun, the leucine zipper region of Meq allows the...

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PMID: 18971275
DOI: 10.1128/jvi.01630-08

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Homodimerization of Marek's Disease Virus-Encoded Meq Protein Is Not Sufficient for Transformation of Lymphocytes in ChickensPMID 18971275Read ↗

Both homo and heterodimers of Marek's disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens.Semantic proximity Read ↗

Homodimerization of the Meq Viral Oncoprotein Is Necessary for Induction of T-Cell Lymphoma by Marek's Disease VirusSemantic proximity Read ↗

Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replicationSemantic proximity Read ↗

Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek's disease virus.Semantic proximity Read ↗

Characterization of the Chromosomal Binding Sites andDimerization Partners of the Viral Oncoprotein Meq in Marek'sDisease Virus-Transformed TCellsSemantic proximity Read ↗

Marek's disease virus Meq transforms chicken cells via the v-Jun transcriptional cascade: A converging transforming pathway for avian oncovirusesSemantic proximity Read ↗

Integrated Analyses of Genome-Wide DNA Occupancy and Expression Profiling Identify Key Genes and Pathways Involved in Cellular Transformation by a Marek's Disease Virus Oncoprotein, MeqSemantic proximity Read ↗

Effect of Insertion and Deletion in the Meq Protein Encoded by Highly Oncogenic Marek’s Disease Virus on Transactivation Activity and VirulenceSemantic proximity Read ↗

A Common Live-Attenuated Avian Herpesvirus Vaccine Expresses a Very Potent OncogeneSemantic proximity Read ↗

Marek’s disease virus: lytic replication, oncogenesis and controlSemantic proximity Read ↗

Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors.Semantic proximity Read ↗

The Oncogenic MicroRNA OncomiR-21 Overexpressed during Marek's Disease Lymphomagenesis Is Transactivated by the Viral Oncoprotein MeqSemantic proximity Read ↗

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