Article
Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sample.
Biological psychiatry - 15 Jan 2006
Puri Vinay, McQuillin Andrew, Thirumalai Srinivasa, Lawrence Jacob, Krasucki Robert, Choudhury Khalid, Datta Susmita, Kerwin Simon, Quested Digby, Bass Nicholas, Pimm Jonathan, Lamb Graham, Moorey Helen, Kandasami Gomathinayagam, Badacsonyi Allison, Kelly Katie, Morgan Jenny, Punukollu Bhaskar, Nadeem Haitham, Curtis David, Gurling Hugh M D
Abstract excerpt
BACKGROUND: Linkage studies have confirmed that chromosome 1q23.3 is a susceptibility locus for schizophrenia. It was then claimed that markers at the carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON) gene showed allelic association with schizophrenia in Canadian families. A second Chinese study found a base pair polymorphism at the CAPON gene also associated with schizophrenia. METHODS: We...
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