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Article

VKORC1 and CYP2C9 genotypes and acenocoumarol anticoagulation status: interaction between both genotypes affects overanticoagulation.

Clinical pharmacology and therapeutics - 1 Jul 2006

Schalekamp Tom, Brassé Bjorn P, Roijers Janine F M, Chahid Youssef, van Geest-Daalderop Johanna H H, de Vries-Goldschmeding Hanneke, van Wijk Eduard M, Egberts Antoine C G, de Boer Anthonius

Abstract excerpt

OBJECTIVE: Our objective was to assess the effects of VKORC1 and CYP2C9 genotypes on severe overanticoagulation and time to achieve stability and their contributions to dose requirement during the initial phase of acenocoumarol treatment. METHODS: A prospective follow-up study was conducted at 2 anticoagulation clinics in The Netherlands. We assessed the CYP2C9 genotype (CYP2C9*2 and CYP2C9*3 polymorphisms) and...

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Source

Identifiers

PMID: 16815313
DOI: 10.1016/j.clpt.2006.04.006

Genes

VKORC1

Variants

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