Article
YrxA is the transcriptional regulator that represses de novo NAD biosynthesis in Bacillus subtilis.
Journal of bacteriology - 1 Oct 2005
Rossolillo Paola, Marinoni Ilaria, Galli Elisa, Colosimo Anna, Albertini Alessandra M
Abstract excerpt
The first genetic, in vivo, and in vitro evidences that YrxA is the regulator of NAD de novo biosynthesis in Bacillus subtilis are hereby reported. The protein is essential to the transcription repression of the divergent operons nadBCA and nifS-yrxA in the presence of nicotinic acid and binds to their shared operator-promoter region.
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