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Article

The HNPCC associated MSH2*1906G-->C founder mutation probably originated between 1440 CE and 1715 CE in the Ashkenazi Jewish population.

Journal of medical genetics - 1 Oct 2005

Sun S, Greenwood C M T, Thiffault I, Hamel N, Chong G, Foulkes W D

Abstract excerpt

The MSH2*1906G-->C mutation was recently shown to be a rare yet highly penetrant mutation leading to colorectal cancer. The mutation was only found among Ashkenazi Jewish individuals and lies on an extended haplotype that is common in that population. This study determined that the mutation proba...

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Share to Colorectal Neoplasms
Share to Colorectal Neoplasms, Hereditary Nonpolyposis
Share to Founder Effect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Linkage Disequilibrium

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Share to MutS Homolog 2 Protein

Source

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Identifiers

PMID: 16199548
DOI: 10.1136/jmg.2005.030999
PMCID: PMC1735921

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16199548-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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