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Article

New founding mutation in MSH2 associated with hereditary nonpolyposis colorectal cancer syndrome on the Island of Tenerife.

Cancer letters - 8 Dec 2006

Medina-Arana Vicente, Barrios Ysamar, Fernández-Peralta Antonia, Herrera Mercedes, Chinea Nancy, Lorenzo Nieves, Jiménez Alejandro, Martín-López Juana Victoria, González-Hermoso Fernando, Salido Eduardo, González-Aguilera Juan J

Abstract excerpt

Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary syndrome with genetic heterogeneity. The disease is caused by mutations or epigenetic silencing in DNA mismatch repair genes, MLH1, MSH2, MSH6, PMS2 and MLH3, although the vast majority of cases correspond to mutations of MLH1 and MSH2. We herein describe a nucleotide change, c.2063T>G in exon 13 of the MSH2 gene, present in...

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Topics

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to MutS Homolog 2 Protein

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 16500024
DOI: 10.1016/j.canlet.2005.12.033

Genes

MSH2
MLH1
MLH3
MSH6
PMS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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